There is no real 'right' to say it, and if she were to decided to do it on her own it would be very difficult for you to go after her legally-speaking. It may be wise for you to try to work out some type of situation where she goes to the Philippines for 3-6 months every year, with the children (maybe during summer break). It would also be advantages for the children to be in touch with their culture.
As far as 'dirtiness' goes, it kind of depends on the area. The cities certainly have air quality problems with all of the diesel jeepneys and 2-cycle motorcycles. There are also clean water and septic issues in some places. But there are ways to compensate for the water issues, depending on funding and location.
More importantly it would probably be wise to find out why she is unhappy on Guam. Frequently it is a lack of friends and family. I am not sure how many Filipinas are there on Guam, but if she has not already made friends there perhaps the two of you should seek some out. Also make sure that she can stay in touch with her family, via Facebook, Skype or whatever.
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Medical Exams – A caller explained that the civil surgeon who completed the medical exam used the wrong form and then wanted to charge an indigent refugee to reprocess the paperwork on the correct form. What recourse does an applicant have if this occurs?
USCIS Response: Customers should notify the Director of their local office when they have a complaint about a civil surgeon.